Upstate South Carolina Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
Top Upstate South Carolina Vacation Deals
Price found within the past 48 hours. Click for updated prices.
Landing Apartments Greer - Sugar Creek
CA $1,277
per person
Oct 2 - Oct 5
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to Greenville (GSP)
9.2/10 Wonderful! (5 reviews)
Great space to rent versus have a hotel room. The unit was very spacious, clean and comfortable. Our only issue was getting an immediate response with an issue discovered at check in. Because Landing had to contact the onsite office for the apartments, we did not receive the pool pass until half way through our visit. It was very disappointing not to be able to use the pool the first two days since we intentionally booked this place for the pool.
Reviewed on Jul 23, 2026
Where to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
2 out of top 10 points of interest in this area
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Nicholtown
If you're spending some time in Nicholtown, Swamp Rabbit Trail and Pleasantburg Shopping Center are top sights worth seeing.
West End
Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river.
Overbrook Historic District
While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Beattie House and Bon Secours Wellness Arena.
Hampton-Pinckney Historic District
Hampton-Pinckney Historic District is well-liked for its historic sites. If you'd like to do some sightseeing in the greater Greenville area, you might plan a trip to The Children’s Museum of the Upstate or The Peace Center.
Ready to book your vacation to Upstate South Carolina?
Stay near popular Upstate South Carolina attractions
Clemson University
9.6/10 (1,439 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
9.6/10 (2,661 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
Photo by Karyn Thompson
Fred W. Symmes Chapel
9.8/10 (29 reviews)
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
Bon Secours Wellness Arena
8.6/10 (1,219 reviews)
Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the acclaimed theater scene in this family-friendly area.
Greenville Convention Center
8.4/10 (571 reviews)
Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.
Haywood Mall
8.8/10 (1,681 reviews)
During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.
What to do in Upstate South Carolina
Paranormal Walking Tour by Greenville Ghost Tours
CA $49
per adult
Frequently asked questions
How much does a Upstate South Carolina vacation package cost?
From as low as CA $1,232. Yes, you read that right. Our Upstate South Carolina vacation packages are the best way to stretch your budget. Bundle your preferred hotels, flights and rental car and get to know this top destination.
How do I get a cheap travel package to Upstate South Carolina?
Our Upstate South Carolina vacation packages mean plenty of savings for the savvy explorer. For the best deal, simply combine your hotel, flights and extras (such as activities) into one neat package. But great bargains are only the start of your next awesome adventure. Book with Expedia and you'll have more than 550 airlines and 1,000,000 hotels around the world to choose from. No matter your style, there's a package with your name on it.
Where should I stay in Upstate South Carolina?
Falls Park on the Reedy is one of the key things that draws people to Upstate South Carolina, so it makes perfect sense that many opt to stay in Greenville.
What are the top hotels in Upstate South Carolina?
When it comes to hotels in Greenville, Best Western Plus Greenville I-385 Inn & Suites and Comfort Inn Greenville - Haywood Mall are two terrific options. If you're heading to Seneca, Quality Inn Seneca US-123 and Tru by Hilton Seneca Clemson will make you feel at home.
How far in advance should I book my Upstate South Carolina vacation?
While prices fluctuate, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to 12 months in advance. If circumstances have left you booking late, you might still be in luck. Cheap journeys to Upstate South Carolina occasionally appear just weeks before departure.
What does an Expedia Upstate South Carolina travel package include?
With Expedia, you can choose any combination of flights, hotels and car rentals to build your ideal Upstate South Carolina travel package. Once you've made your booking, you can add on the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the more dollars you'll save!
What should I know before booking a Upstate South Carolina travel package?
Design deals that suit your budget with an Expedia package. Hotels, flights, rental cars — we're a one-stop shop for all of them. You'll save big bucks just by bundling your bookings. Whether you're embarking on an adventure in the snow or getting some sun on a warm beach, your dream getaway is just a few clicks away.
Can I choose my airline with a Upstate South Carolina Expedia vacation package?
Yes — that's one of the best things about an Expedia vacation package. You can mix and match your flights, hotels and more. We have more than 550 airline partners throughout the world, so you have lots of choice when putting together your Upstate South Carolina getaway.
If I'm not able to travel, can I cancel my Upstate South Carolina vacation package?
Yes, you can cancel your Upstate South Carolina booking if your plans have changed. Whether you'll incur a fee or not depends on your hotel, airline or car rental company. It may be possible to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.
Explore a world of travel with Expedia
- Farmstay in Greenville
- 2 Bed near Greenville
- Mint House Greenville Downtown by Kasa
- Golf Hotels in Greenville - Spartanburg
- Hotels near Christ Episcopal Church
- Safari Tentalow in Greenville
- 2br Cedar Lane Road Retreat at Swamp Rabbit Trail!
- Hotels near Bon Secours Wellness Arena
- Hotels near Centre Stage
- Judson Mill Lofts with all the amenities
- Accor Hotels in Greenville
- Simpsonville Hotels
- Luxe Mountain getaway only 15 minutes from the city!
- Hotels with Free Airport Shuttle in Greenville - Spartanburg
- Cabin Rentals in Greenville - Spartanburg
- Adults Only Resorts & in Greenville
- Hotels with Free Airport Shuttle in Greenville
- Cabin Rentals in Greenville
- Tru by Hilton Greenville Woodruff Road
- Bright Greenville Apt w/ Balcony
- All Inclusive Resorts and in Greenville
- B&B in Greenville
- Beach Hotel Hotels in Greenville
- 5 Star Hotels in Greenville
- Hotels with Free Breakfast in Greenville
- Hotel Wedding Venues Hotels in Colonel Elias Earle Historic District
- Greenville Downtown Hotels
- Ac Hotel By Marriott Greenville
- 24 Riverview Dr
- Cozy Hub~Comfortable Simpsonville Home ~Long-Term Stays Welcome ~Community Pool
- Five Forks Hotels
- Spa Hotels in Upstate South Carolina
- Motels in Greenville
- 3 Star Hotels in Greenville
- Greenville Hotels
- 4 Star Hotels in West End
- Apartments in Greenville
- Flights to Greenville
- Flights from Ottawa (YOW) to Greenville (GSP)
- Flights from Buffalo (BUF) to Greenville (GSP)
- Flights from Philadelphia (PHL) to Greenville (GMU)
- Flights from West Palm Beach (PBI) to Greenville (GMU)
- Flights from Greenville - Spartanburg
- Flights from Donaldson Center
- Flights from Annapolis (ANP) to Greenville (GMU)
- Flights from Vancouver (YVR) to Greenville (GMU)
- Flights from Manteo (MEO) to Greenville (GMU)
- Flights to Greenville - Spartanburg
- Flights from Miami (MIA) to Greenville (GDC)
- Flights from Des Moines (DSM) to Greenville (GDC)
- Flights from Washington (DCA) to Greenville (GDC)
- Flights from Detroit (DTW) to Greenville (GSP)
- Flights from Anderson (AND) to Greenville (GDC)
- Flights from Orlando (MCO) to Greenville (GDC)
- Flights from New York (JFK) to Greenville (GMU)
- Flights from Schenectady (SCH) to Greenville (GMU)
- Flights from Vancouver (YVR) to Greenville (GSP)
- Flights to Simpsonville
- Flights from Birmingham (BHM) to Greenville (GMU)
- Flights from Rome (FCO) to Greenville (GDC)
- Flights from Toronto (YYZ) to Greenville (GMU)
- Flights from Montreal (YUL) to Greenville (GSP)
- Flights from San Diego (SAN) to Greenville (GMU)
- Flights from Detroit (DTW) to Greenville (GDC)
- Flights from Montreal (YUL) to Greenville (GMU)
- Flights from Toronto (YYZ) to Greenville (GSP)
- Flights from Raleigh (RDU) to Greenville (GDC)
- Flights from Greenville-Spartanburg Intl.
- Flights from Greenville
- North Greenville University
- Ski Vacation Packages Greenville - Spartanburg
- Greenville Vacations
- Fred W. Symmes Chapel
- Central Vacations
- Discovery Island Water Park
- Welcome Vacations
- Visit Greenville Downtown
- La France Vacations
- Visit Greenville
- Anderson Vacations
- Adults Only Vacation Packages Upstate South Carolina
- Ace Rental Cars in Greenville Downtown
- Enterprise Rental Cars in Greenville Downtown
- Drive on Holidays Rental Cars in Greenville - Spartanburg
- Car rentals near Prisma Health Greenville Memorial Hospital
- Routes Rental Cars in Greenville - Spartanburg
- Car rental Greenville
- Enterprise Rental Cars in Greenville
- Wiber Rental Cars in Greenville
- Avis Rental Cars in Greenville
- Car rental Simpsonville
- Europcar Rental Cars in Greenville
- Rental cars Greenville-Spartanburg Intl. airport
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
