Upstate South Carolina Vacation Packages

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Your Upstate South Carolina Vacation

When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.

Top Upstate South Carolina Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
Price was CA $1,247, price is now CA $943 per person
CA $943
per person
Apr 28 - May 5
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Greenville (GSP)
8.6/10 Excellent! (1,005 reviews)
Courteous staff, clean room

Reviewed on Feb 8, 2026

Hotel Hartness

Hotel Hartness

4 out of 5
Price was CA $2,505, price is now CA $1,791 per person
CA $1,791
per person
Apr 28 - May 5
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Greenville (GSP)
9.8/10 Exceptional! (613 reviews)
Everything was great as usual this is our third year. We will be back again next year for our anniversary.

Reviewed on Jan 6, 2026

Landing Apartments - Lyman

Landing Apartments - Lyman

3 out of 5
Price was CA $1,454, price is now CA $1,148 per person
CA $1,148
per person
Apr 28 - May 5
found 6 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to Greenville (GSP)
No reviews
Hampton Inn Greenville I-385 - Woodruff Rd.

Hampton Inn Greenville I-385 - Woodruff Rd.

3 out of 5
Price was CA $1,554, price is now CA $1,259 per person
CA $1,259
per person
Apr 28 - May 5
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Greenville (GSP)
8.8/10 Excellent! (786 reviews)
Clean bathroom, spacious room.

Reviewed on Jan 29, 2026

Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Always thinking on how I traveled half way across the world just to come and study. Sometimes I think of home and I miss it sooo much. But, this is the area I have lived for the last 3 years. This is the home far from home. I call this home, not because I have family here. It is where I have met so many wonderful people in this city. This is my #adventure from one side of the world to here!

Greenville Downtown

2 out of top 10 points of interest in this area
5/5(3 area reviews)

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

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Upstate South Carolina Hotel Deals

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
The price is CA $354 per night from Feb 23 to Feb 24
CA $354
CA $400 total
Feb 23 - Feb 24
includes taxes & fees
9.4/10 Exceptional! (444 reviews)
Beautiful as soon you walk in and the rooms were great. Great location.

Reviewed on Feb 7, 2026

Grand Bohemian Lodge Greenville, Autograph Collection
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
The price is CA $197 per night from Feb 22 to Feb 23
CA $197
CA $223 total
Feb 22 - Feb 23
includes taxes & fees
8.6/10 Excellent! (1,000 reviews)
The staff was great to us during the ice storm! Lots of places to hang out.

Reviewed on Jan 28, 2026

Hyatt Regency Greenville
Sleep Inn Spartanburg Southwest

Sleep Inn Spartanburg Southwest

2.5 out of 5
501 South Blackstock Rd Spartanburg SC
Fully refundable
The price is CA $80 per night from Feb 15 to Feb 16
CA $80
CA $89 total
Feb 15 - Feb 16
includes taxes & fees
5.8/10 (538 reviews)
Room was very spotless and clean great staff and pet friendly hotel i would recommend anyone to come here 😀 me and my girlfriend had an amazing stay

Reviewed on Jan 28, 2026

Sleep Inn Spartanburg Southwest
See all 2,945 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Upstate South Carolina

At the foot of the Cross lies my peace... A popular place for weddings in the small open-sided chapel atop the mountain at the YMCA camp. To sit in the pews and look out on the world is a great side of peace. #cross #peace #mountains #SC #relaxing #beautifulday #outdoors #traveljunkie #ktphoenixphotography

Fred W. Symmes Chapel

You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.

Fred W. Symmes Chapel

Prisma Health Greenville Memorial Hospital

Though Prisma Health Greenville Memorial Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Greenville while you are here.

Prisma Health Greenville Memorial Hospital

Greenville Convention Center

Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.

Greenville Convention Center

What to do in Upstate South Carolina

Paranormal Walking Tour by Greenville Ghost Tours

Paranormal Walking Tour by Greenville Ghost Tours

CA $48
per adult
Paranormal Walking Tour by Greenville Ghost Tours
Just Desserts Tour In Greenville

Just Desserts Tour In Greenville

CA $130
per adult
Just Desserts Tour In Greenville
Greenville: Saturday Morning Breakfast Tour

Greenville: Saturday Morning Breakfast Tour

CA $123
per adult
Greenville: Saturday Morning Breakfast Tour
See all activities in Upstate South Carolina

Frequently asked questions

Can I cancel my flight booking to Upstate South Carolina due to COVID-19?
Head to our Customer Service Portal for important information about changing or canceling flights due to COVID-19. Make sure you also read through the terms and conditions of your chosen airline before booking your fare to Upstate South Carolina.
What's the best way to find cheap flights to Upstate South Carolina that have flexible change policies?
We understand that travel plans can change in the blink of an eye, so reserving a flexible ticket with Expedia is a sensible idea. Simply tick the "No change fee" box under the "Flexible change policies" filter. Your low-cost, flexible flight to Upstate South Carolina is just a few clicks away.
What are some of the general tips for travelers to Upstate South Carolina during the COVID-19 outbreak?
COVID-19 has affected how the world works in endless ways, and travel has changed with it. These tips will help you navigate these new challenges and prepare you for your trip to Upstate South Carolina:
  • Before booking anything, see if any travel bans or restrictions apply — in both your origin and destination. Get up-to-date information by reviewing government and travel websites.
  • Wear a face mask even during airport screening. A TSA employee will require you to lower your mask temporarily to verify your identity.
  • You're no longer required to hand your boarding pass (paper or electronic) directly to a TSA officer. Rather, place your pass on the scanner and then hold it up for inspection.
  • One container of liquid hand sanitizer is now allowed in your carry-on luggage. It must not be larger than 12 oz (350 ml), and you'll need to remove it from your bag for screening.
  • To reduce handling during screening, place items such as your phone and loose change into your carry-on rather than the bins.
  • Separate any food you're carrying for X-ray screening. Placing it in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings.

Which airlines fly to Upstate South Carolina?
Secure your ticket with American Airlines and then start piecing together your Upstate South Carolina itinerary. This leading carrier offers 19932 flights each month to Charlotte-Douglas Intl. Airport (CLT), a key gateway.
How can I find cheap tickets to Upstate South Carolina?
You'll always nab a fabulous deal with Expedia, but our "flexible dates" feature makes it that much easier. Enter your preferred flight date, then check the flexible dates box above to see a list of prices for nearby days. was the lowest price for a flight to Upstate South Carolina in the last seven days.
How much is a flight to Upstate South Carolina?
One-way trips departing from () sold for as little as in the last seven days. During this period, the price of a round-trip fare to Upstate South Carolina ranged between and . If you find a bargain ticket, book as fast as you can — these prices don't stick around.
What are the most popular airports to fly into in Upstate South Carolina?
Book your flight to Charlotte-Douglas Intl. Airport (CLT) and experience everything that Upstate South Carolina has to offer. As the region's primary entry point, about 21666 flights touch down here every month.
When is the cheapest time to fly to Upstate South Carolina?
If you'd prefer to spend your hard-earned vacation money experiencing the delights of Upstate South Carolina rather than on your trip there, leave early in the week. The most affordable day to travel is normally Tuesday, with Monday coming in second. With many people traveling over the weekend, Saturday often has the costliest fares.
How much is a plane ticket to Upstate South Carolina?
Plane fares ranged anywhere from to in the last seven days. When you're ready to book, we'll help you find a low-cost flight to Upstate South Carolina.
Which airlines with flights to Upstate South Carolina employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, many airlines have introduced new rules and standards to help everybody get back in the skies. These carriers include:
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.