Upstate South Carolina Vacation Packages

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Your Upstate South Carolina Vacation

When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.

Top Upstate South Carolina Vacation Deals

Price found within the past 48 hours. Click for updated prices.
AutoCamp Asheville
Grand Bohemian Lodge Asheville, Autograph Collection®
The Restoration Asheville
The Foundry Hotel Asheville, Curio Collection by Hilton
Kimpton Hotel Arras by IHG

Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina

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Upstate South Carolina Hotel Deals

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
The price is CA $106 per night from Dec 6 to Dec 7
CA $106
CA $117 total
Dec 6 - Dec 7
includes taxes & fees
9.2/10 Wonderful! (1,616 reviews)
"Room was nice and tidy. Breakfast was good. Parking was convenient. Overall a very good experience."

Reviewed on Nov 8, 2026

Best Western Plus Greenville I-385 Inn & Suites
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd Greenville SC
Fully refundable
The price is CA $137 per night from Dec 10 to Dec 11
CA $137
CA $155 total
Dec 10 - Dec 11
includes taxes & fees
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Days Inn by Wyndham Greenville

Days Inn by Wyndham Greenville

2 out of 5
60 Roper Mountain Rd Greenville SC
Fully refundableReserve now, pay when you stay
The price is CA $88 per night from Nov 29 to Nov 30
CA $88
CA $96 total
Nov 29 - Nov 30
includes taxes & fees
5.6/10 (1,001 reviews)
"Always a great stay"

Reviewed on Nov 6, 2026

Days Inn by Wyndham Greenville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Upstate South Carolina attractions

What to do in Upstate South Carolina

Frequently asked questions

How much does a Upstate South Carolina vacation package cost?
From as low as CA $1,348. Yes, you read that right. Our Upstate South Carolina vacation packages are the best way to stretch your budget. Bundle your preferred hotels, flights and rental car and get to know this top destination.
How do I get a cheap travel package to Upstate South Carolina?
Our Upstate South Carolina vacation packages mean plenty of savings for the savvy explorer. For the best deal, simply combine your hotel, flights and extras (such as activities) into one neat package. But great bargains are only the start of your next awesome adventure. Book with Expedia and you'll have more than 550 airlines and 1,000,000 hotels around the world to choose from. No matter your style, there's a package with your name on it.
Where should I stay in Upstate South Carolina?
Falls Park on the Reedy is one of the key things that draws people to Upstate South Carolina, so it makes perfect sense that many opt to stay in Greenville.
What are the top hotels in Upstate South Carolina?
When it comes to hotels in Greenville, Best Western Plus Greenville I-385 Inn & Suites and Comfort Inn Greenville - Haywood Mall are two terrific options. If you're heading to Seneca, Quality Inn Seneca US-123 and Tru by Hilton Seneca Clemson will make you feel at home.
How far in advance should I book my Upstate South Carolina vacation?
While prices fluctuate, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to 12 months in advance. If circumstances have left you booking late, you might still be in luck. Cheap journeys to Upstate South Carolina occasionally appear just weeks before departure.
What does an Expedia Upstate South Carolina travel package include?
With Expedia, you can choose any combination of flights, hotels and car rentals to build your ideal Upstate South Carolina travel package. Once you've made your booking, you can add on the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the more dollars you'll save!
What should I know before booking a Upstate South Carolina travel package?
Design deals that suit your budget with an Expedia package. Hotels, flights, rental cars — we're a one-stop shop for all of them. You'll save big bucks just by bundling your bookings. Whether you're embarking on an adventure in the snow or getting some sun on a warm beach, your dream getaway is just a few clicks away.
Can I choose my airline with a Upstate South Carolina Expedia vacation package?
Yes — that's one of the best things about an Expedia vacation package. You can mix and match your flights, hotels and more. We have more than 550 airline partners throughout the world, so you have lots of choice when putting together your Upstate South Carolina getaway.
If I'm not able to travel, can I cancel my Upstate South Carolina vacation package?
Yes, you can cancel your Upstate South Carolina booking if your plans have changed. Whether you'll incur a fee or not depends on your hotel, airline or car rental company. It may be possible to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.