Upstate South Carolina Vacation Packages

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Your Upstate South Carolina Vacation

When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.

Top Upstate South Carolina Vacation Deals

Price found within the past 48 hours. Click for updated prices.
MainStay Suites Greenville Airport

MainStay Suites Greenville Airport

2.5 out of 5
per person
Jul. 10 - Jul. 13
found 20 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to Greenville (GSP)
7.6/10 Good! (498 reviews)
I loved the room's layout and the full-sized fridge! I didn't realize my shower was lacking a curtain until it was too close to checkout to obtain one. Also, I left my room to obtain a luggage cart and could not re-enter. I had to walk back to the front desk to reactivate the keycard. I wish places wouldn't deactivate prior to checkout time - it is annoying and adds delay to an already hectic morning.

Reviewed on Apr. 28, 2025

Hotel Hartness

Hotel Hartness

4 out of 5
per person
Jul. 10 - Jul. 13
found 20 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to Greenville (GSP)
9.8/10 Exceptional! (480 reviews)
I travel to Greenville, South Carolina quite a bit and this property is by far the best place to stay while in Greenville.

Reviewed on Apr. 26, 2025

La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

2.5 out of 5
per person
Jul. 10 - Jul. 13
found 20 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to Greenville (GSP)
7.4/10 Good! (1,003 reviews)
The motel seemed a little older. The breakfast was not special but the rooms were clean and at least there was breakfast. It was a little cheaper than some motels but you get what you pay for. If you are looking for someplace to stay a little less expensive it is a good choice.

Reviewed on Apr. 21, 2025

Holiday Inn Greenville - Woodruff Road by IHG

Holiday Inn Greenville - Woodruff Road by IHG

3 out of 5
per person
Jul. 10 - Jul. 13
found 20 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to Greenville (GSP)
8.6/10 Excellent! (498 reviews)
Very nice hotel. Quiet rooms. Even being located on a busy road there was no highway traffic noise. Will book here again.

Reviewed on Apr. 14, 2025

Tanglewood Inn

Tanglewood Inn

3 out of 5
per person
Jul. 10 - Jul. 13
found 20 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to Greenville (GSP)
10/10 Exceptional! (1 review)

Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville featuring autumn leaves, a garden and a bridge

Greenville Downtown

2 out of top 10 points of interest in this area
5/5(3 area reviews)

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

Ready to book your vacation to Upstate South Carolina?

 

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Upstate South Carolina Hotel Deals

Hilton Greenville
Hilton Greenville
3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is CA $168 per night from May 25 to May 26
CA $168
CA $190 total
includes taxes & fees
May 25 - May 26
8/10 Very Good! (1,000 reviews)
"Hilton Greenville was very nice and superb staff"

Reviewed on Apr. 20, 2025

Hilton Greenville
Hyatt Regency Greenville
Hyatt Regency Greenville
3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is CA $187 per night from May 25 to May 26
CA $187
CA $212 total
includes taxes & fees
May 25 - May 26
8.6/10 Excellent! (1,000 reviews)
"My pet peeve is always shower heads. I prefer stronger, not gentler."

Reviewed on Apr. 19, 2025

Hyatt Regency Greenville
Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection
4 out of 5
44 EAST CAMPERDOWN WAY, Greenville, SC
The price is CA $335 per night from May 25 to May 26
CA $335
CA $368 total
includes taxes & fees
May 25 - May 26
9.4/10 Exceptional! (336 reviews)
"Great place, expensive but worth it"

Reviewed on Apr. 21, 2025

Grand Bohemian Lodge Greenville, Autograph Collection
See all 2,611 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Frequently asked questions

How much does a Upstate South Carolina vacation package cost?
From as low as CA $744. Yes, you read that right. Our Upstate South Carolina vacation packages are the best way to stretch your budget. Bundle your preferred hotels, flights and rental car and get to know this top destination.
How do I get a cheap travel package to Upstate South Carolina?
Our Upstate South Carolina vacation packages mean plenty of savings for the savvy explorer. For the best deal, simply combine your hotel, flights and extras (such as activities) into one neat package. But great bargains are only the start of your next awesome adventure. Book with Expedia and you’ll have more than 550 airlines and 1,000,000 hotels around the world to choose from. No matter your style, there’s a package with your name on it.
Where should I stay in Upstate South Carolina?
Falls Park on the Reedy is one of the key things that draws people to Upstate South Carolina, so it makes perfect sense that many opt to stay in Greenville.
What are the top hotels in Upstate South Carolina?
When it comes to hotels in Greenville, Best Western Plus Greenville I-385 Inn & Suites and Comfort Inn Greenville - Haywood Mall are two terrific options. If you’re heading to Seneca, Quality Inn Seneca US-123 and Tru by Hilton Seneca Clemson will make you feel at home.
How far in advance should I book my Upstate South Carolina vacation?
While prices fluctuate, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to 12 months in advance. If circumstances have left you booking late, you might still be in luck. Cheap journeys to Upstate South Carolina occasionally appear just weeks before departure.
What does an Expedia Upstate South Carolina travel package include?
With Expedia, you can choose any combination of flights, hotels and car rentals to build your ideal Upstate South Carolina travel package. Once you’ve made your booking, you can add on the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the more dollars you’ll save!
What should I know before booking a Upstate South Carolina travel package?
Design deals that suit your budget with an Expedia package. Hotels, flights, rental cars — we’re a one-stop shop for all of them. You’ll save big bucks just by bundling your bookings. Whether you’re embarking on an adventure in the snow or getting some sun on a warm beach, your dream getaway is just a few clicks away.
Can I choose my airline with a Upstate South Carolina Expedia vacation package?
Yes — that’s one of the best things about an Expedia vacation package. You can mix and match your flights, hotels and more. We have more than 550 airline partners throughout the world, so you have lots of choice when putting together your Upstate South Carolina getaway.
If I'm not able to travel, can I cancel my Upstate South Carolina vacation package?
Yes, you can cancel your Upstate South Carolina booking if your plans have changed. Whether you’ll incur a fee or not depends on your hotel, airline or car rental company. It may be possible to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.

Discover the most popular places to visit in Upstate South Carolina

Fred W. Symmes Chapel

Fred W. Symmes Chapel

You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.

Fred W. Symmes Chapel

Prisma Health Greenville Memorial Hospital

Though Prisma Health Greenville Memorial Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Greenville while you are here.

Prisma Health Greenville Memorial Hospital

Greenville Convention Center

Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.

Greenville Convention Center

What to do in Upstate South Carolina

Paranormal Walking Tour by Greenville Ghost Tours

Paranormal Walking Tour by Greenville Ghost Tours

CA $48
per adult
Paranormal Walking Tour by Greenville Ghost Tours
Greenville on the Go A 1 Hour Rydable Adventure

Greenville on the Go A 1 Hour Rydable Adventure

CA $76
per adult
Greenville on the Go A 1 Hour Rydable Adventure
Cheers! There's always something to celebrate.

Thirsty Thursdays Tour (cocktails and appetizers)

CA $145
per adult
100% of travellers recommend
Thirsty Thursdays Tour (cocktails and appetizers)
See all activities in Upstate South Carolina
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.